Methylene Blue – Safety Information & Medication Interactions
Possible Side Effects of Methylene Blue:
• Headache
• Nausea
• Dizziness or lightheadedness
• Vomiting
• Diarrhea
• Temporary blue or green urine discoloration
• Increased heart rate (rare)
• Agitation or restlessness (at higher doses)
Important Medication Interactions – Especially with Mental Health Medications:
⚠️ Methylene blue can interact dangerously with medications that increase serotonin levels, potentially causing a serious condition known as serotonin syndrome.
DO NOT take methylene blue if you are currently using:
• SSRIs (e.g., Fluoxetine, Sertraline, Citalopram)
• SNRIs (e.g., Venlafaxine, Duloxetine)
• MAOIs (e.g., Phenelzine, Tranylcypromine)
• Tricyclic Antidepressants (e.g., Amitriptyline, Nortriptyline)
• Other serotonin-boosting medications or supplements
Symptoms of Serotonin Syndrome May Include:
• Confusion
• Rapid heart rate
• High blood pressure
• Muscle rigidity or twitching
• Sweating or fever
• Tremors or agitation
Always Consult Your Doctor First:
If you are taking any mental health medications, consult your healthcare provider before using methylene blue. Even at low doses, interactions can occur. Your safety comes first.
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